House Majority Leader John Boehner (R-Ohio) urged Treasury Secretary Timothy Geithner to resign during a speech Tuesday in Cleveland.

The administration, unsurprisingly, indicated that it's not inclined to follow his advice on personnel.

"The American people are asking 'where are the jobs' and all the president's economic team has to offer are promises of 'green shoots' that never seem to grow," Boehner said, in prepared remarks that were posted on his website. "The worse things get, the more they circle the wagons and defend the indefensible."

Boehner spoke at the City Club of Cleveland, which has hosted many presidents and other political leaders over the years.

"President Obama should ask for - and accept - the resignations of the remaining members of his economic team, starting with Secretary Geithner and Larry Summers, the head of the National Economic Council," Boehner said.

In addition to calling for the resignations, Boehner also reiterated many conservative talking points, reiterating his desire for the extension of Bush-era tax cuts and reduced government spending.

The crux of Boehner's speech centered around small businesses, and the Ohio congressman argued that uncertainty about the economy has prevented them from being able to hire more workers.

"It's time to put grown-ups in charge," Boehner said. "It's time for people willing to accept responsibility. It's time to do what we say we're going to do."

Following Boehner's speech, Rep. Connie Mack (R-Fla.) called for Geithner's resignation as well. He first pushed for the Treasury Secretary to resign in March 2009.

Mack cited Geithner's role in the bailout of American International Group Inc. and "his mishandling of the economic recovery" as reasons for his to step down.

Shortly after Boehner's speech, Vice President Joe Biden sarcastically dismissed Boehner's comments. "Very constructive advice -- thanks," Biden said, according to prepared remarks.

He accused Boehner and other Republican leaders of being responsible for the economic slump, and argued that they are responsible for allowing the economy to slide under eight years of President George W. Bush's leadership.

"Mr. Boehner is nostalgic for those good old days...the American people are not," Biden said. "They don't want to go back. They want to move forward."